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Article

Serine protease inhibitor Kazal type 1 mutations and pancreatitis.

Gastroenterology clinics of North America - 1 Dec 2004

Schneider Alexander

Abstract excerpt

In summary, SPINK1 is thought to play an important role in protecting the pancreas against excessive trypsinogen activation. SPINK1 mutations are associated with the development of acute and chronic pancreatitis and have been detected in all forms of chronic pancreatitis. The strong association of mutations in the PRSS1 gene and in the SPINK1 gene with chronic pancreatitis supports the concept of intracellular...

Topics

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Chronic Disease
Enzyme Activation
Enzyme Precursors
PRSS1 gene
Genetic Testing
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Trypsin Inhibitor, Kazal Pancreatic

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Identifiers

PMID: 15528018
DOI: 10.1016/j.gtc.2004.07.005

Genes

SPINK1
CFTR
PRSS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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