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Article

SPINK1, ADH2, and ALDH2 gene variants and alcoholic chronic pancreatitis in Japan.

Journal of gastroenterology and hepatology - 1 Mar 2008

Shimosegawa Tooru, Kume Kiyoshi, Masamune Atsushi

Abstract excerpt

The serine protease inhibitor Kazal type 1 (SPINK1) is a potent antiprotease and an important inactivation factor of intrapancreatic trypsin activity. Loss of function by the SPINK1 mutations leads to decreased inhibitory capacity. The significance of SPINK1 mutations in alcoholic chronic pancreatitis (CP) in Japan and its functional role remain unclear. The aim of the present study was to clarify the incidence...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Pancreatitis, Alcoholic

Share to Trypsin Inhibitor, Kazal Pancreatic

Source

Identifiers

PMID: 18336671
DOI: 10.1111/j.1440-1746.2007.05291.x

Genes

SPINK1
ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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