Serine protease inhibitor kazal type 1 mutations and pancreatitis.

doi:10.1016/j.cll.2004.12.005

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Article

Serine protease inhibitor kazal type 1 mutations and pancreatitis.

Clinics in laboratory medicine - 1 Mar 2005

Schneider Alexander

Abstract excerpt

SPINKI is thought to play an important role in protecting the pancreas against excessive trypsinogen activation. SPINK1 mutations are associated with the development of acute and chronic pancreatitis and have been detected in all forms of chronic pancreatitis. The strong association of mutations in the PRSS1 gene and in the SPINKI gene with chronic pancreatitis supports the concept of intracellular trypsin...

Topics

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Carrier Proteins
Chronic Disease
CFTR gene
PRSS1 gene
SPINK1 gene
Mutation
Pancreatitis
Trypsin Inhibitor, Kazal Pancreatic

Source

Open in PubMed

Identifiers

PMID: 15749232
DOI: 10.1016/j.cll.2004.12.005

Genes

SPINK1
CFTR
PRSS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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