Article
Genetic polymorphisms of the matrix metalloproteinase-3 (MMP-3) and tissue inhibitors of matrix metalloproteinases-1 (TIMP-1) modulate the development of ankylosing spondylitis.
Annals of the rheumatic diseases - 1 Nov 2009
Wei J C-C, Lee H-S, Chen W-C, Shiu L-J, Yang S-F, Wong R-H
Abstract excerpt
BACKGROUND: The aetiology of ankylosing spondylitis (AS) remains unclear. Inflammation progresses to fibrosis and calcification of the spine and sacroiliac joints in AS development. Fibrosis results from excessive accumulations of the extracellular matrix (ECM). ECM turnover depends on the balance between matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). OBJECTIVE: To evaluate the effects of...
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