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CALR mutations in patients with essential thrombocythemia diagnosed in childhood and adolescence

5 Jun 2014

Abstract excerpt

After the recent discovery of various mutations of theCALRgene,,10% of adult patients with essential thrombocythemia (ET) orprimary myelofibrosis carry no identified molecular markers.1,2More rarely, ET may occur also in children and adolescents.3Weevaluated, by Sanger sequencing, the mutation status of exon 9 oftheCALRgene in 34 ET patients younger than 20 years of age atdiagnosis (median age, 15 years; range,...

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PMID: 24904106
DOI: 10.1182/blood-2014-04-572040

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