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Article

CALR exon 9 mutations are somatically acquired events in familial cases of essential thrombocythemia or primary myelofibrosis.

Blood - 10 Apr 2014

Rumi Elisa, Harutyunyan Ashot S, Pietra Daniela, Milosevic Jelena D, Casetti Ilaria C, Bellini Marta, Them Nicole C C, Cavalloni Chiara, Ferretti Virginia V, Milanesi Chiara, Berg Tiina, Sant'Antonio Emanuela, Boveri Emanuela, Pascutto Cristiana, Astori Cesare, Kralovics Robert, Cazzola Mario

Abstract excerpt

Somatic mutations in the calreticulin (CALR) gene were recently discovered in patients with sporadic essential thrombocythemia (ET) and primary myelofibrosis (PMF) lacking JAK2 and MPL mutations. We studied CALR mutation status in familial cases of myeloproliferative neoplasm. In a cohort of 127 patients, CALR indels were identified in 6 of 55 (11%) subjects with ET and in 6 of 20 (30%) with PMF, whereas 52 cases...

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Source

Identifiers

PMID: 24553179
DOI: 10.1182/blood-2014-01-550434

Genes

CALR
JAK2
MPL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CALR exon 9 mutations are somatically acquired events in familial cases of essential thrombocythemia or primary myelofibrosis.PMID 24553179Read ↗

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Incidence, clinical features, and prognostic impact of CALR exon 9 mutations in essential thrombocythemia and primary myelofibrosis: an experience of a single tertiary hospital in Korea.Semantic proximity Read ↗

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