Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of the podocyte-expressed transcription factor Tcf21/Pod1 results in podocyte differentiation defects and FSGS.

Journal of the American Society of Nephrology : JASN - 1 Nov 2014

Maezawa Yoshiro, Onay Tuncer, Scott Rizaldy P, Keir Lindsay S, Dimke Henrik, Li Chengjin, Eremina Vera, Maezawa Yuko, Jeansson Marie, Shan Jingdong, Binnie Matthew, Lewin Moshe, Ghosh Asish, Miner Jeffrey H, Vainio Seppo J, Quaggin Susan E

Abstract excerpt

Podocytes are terminally differentiated cells with an elaborate cytoskeleton and are critical components of the glomerular barrier. We identified a bHLH transcription factor, Tcf21, that is highly expressed in developing and mature podocytes. Because conventional Tcf21 knockout mice die in the perinatal period with major cardiopulmonary defects, we generated a conditional Tcf21 knockout mouse to explore the role...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Transcription Factors
Share to Cellular Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Experimental

Share to Glomerulosclerosis, Focal Segmental

Share to Kidney Glomerulus

Share to Lac Operon

Share to Podocytes

Share to Proteinuria

Source

Open in PubMed Open full text

Identifiers

PMID: 24904088
DOI: 10.1681/ASN.2013121307
PMCID: PMC4214535

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of the podocyte-expressed transcription factor Tcf21/Pod1 results in podocyte differentiation defects and FSGS.PMID 24904088Read ↗

Transcription factor 21 deletion from podocyte precursors as a model for congenital nephrotic syndrome.Semantic proximity Read ↗

Transcription Factor 21 Is Required for Branching Morphogenesis and Regulates the Gdnf-Axis in Kidney DevelopmentSemantic proximity Read ↗

Transcription factor 21 expression in injured podocytes of glomerular diseasesSemantic proximity Read ↗

The basic-helix-loop-helix protein pod1 is critically important for kidney and lung organogenesis.Semantic proximity Read ↗

Developmental disorder of podocytes and the related renal diseases.Semantic proximity Read ↗

Transcriptional regulation of podocyte specification and differentiationSemantic proximity Read ↗

Loss of CLDN5 in podocytes deregulates WIF1 to activate WNT signaling and contributes to kidney diseaseSemantic proximity Read ↗

The bHLH transcription factor Tcf21 is required for lineage-specific EMT of cardiac fibroblast progenitors.Semantic proximity Read ↗

Activation of podocyte Notch mediates early Wt1 glomerulopathySemantic proximity Read ↗

Altering a histone H3K4 methylation pathway in glomerular podocytes promotes a chronic disease phenotype.Semantic proximity Read ↗

Epigenetic transcriptional reprogramming by WT1 mediates a repair response during podocyte injurySemantic proximity Read ↗

Epigenetic transcriptional reprogramming by WT1 mediates a repair response during podocyte injurySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.