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Article

Structural insight into the tetramerization of an iterative ketoreductase siam through aromatic residues in the interfaces.

PloS one - 1 Jan 2014

Wang Hua, Zhang Huaidong, Zou Yi, Mi Yanling, Lin Shuangjun, Xie Zhixiong, Yan Yunjun, Zhang Houjin

Abstract excerpt

In the biosynthesis of polyketides, ketoreductases (KRs) are an important group of enzymes that determine the chiralities of the carbon backbones. SiaM is a special member of this group that can recognize substrates with different lengths and can be used iteratively. Here we report the crystal structure of SiaM. Structural analysis indicates that the overall structure resembles those of other KRs. However,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24901639
DOI: 10.1371/journal.pone.0097996
PMCID: PMC4046962

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