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Article

Lessons from McCune-Albright syndrome-associated intraductal papillary mucinous neoplasms: : GNAS-activating mutations in pancreatic carcinogenesis.

JAMA surgery - 1 Aug 2014

Parvanescu Alina, Cros Jérôme, Ronot Maxime, Hentic Olivia, Grybek Virginie, Couvelard Anne, Levy Philippe, Chanson Philippe, Ruszniewski Philippe, Sauvanet Alain, Gaujoux Sebastien

Abstract excerpt

GNAS-activating mutations are reported in intraductal papillary mucinous neoplasms (IPMNs) and in McCune-Albright syndrome, characterized by fibrous dysplasia, precocious puberty, and café au lait spots. Recently, IPMNs have been described as a McCune-Albright syndrome-associated tumor, present in about 15% of patients. The aim of the present work was to assess the prevalence of polyostotic fibrous dysplasia and...

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Share to Adenocarcinoma, Mucinous
Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Papillary

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Share to Fibrous Dysplasia, Polyostotic

Share to GTP-Binding Protein alpha Subunits, Gs

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Source

Identifiers

PMID: 24898823
DOI: 10.1001/jamasurg.2014.535

Genes

GNAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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