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Actionable Gene Alterations in Resected Non-Small Cell Lung Cancer: Primary Results From the AGA-R Study.

Clinical lung cancer - 1 Mar 2026

Attili Ilaria, Pellizzari Gloria, Bertolaccini Luca, Corvaja Carla, Vacirca Davide, Lombardi Mariano, Spitaleri Gianluca, Trillo Aliaga Pamela, Del Signore Ester, Passaro Antonio, Guarize Juliana, Guerini-Rocco Elena, Fusco Nicola, Spaggiari Lorenzo, de Marinis Filippo

Abstract excerpt

INTRODUCTION: In resected non-small cell lung cancer (NSCLC), molecular testing is currently limited to EGFR mutations and ALK rearrangements, as these guide approved adjuvant therapies. The role of next-generation sequencing (NGS), routinely used in metastatic NSCLC, remains unclear in earlier stages. The prevalence of other driver mutations and their impact on outcomes is not well established. METHODS: We...

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PMID: 41173737
DOI: 10.1016/j.cllc.2025.09.015

Genes

EGFR
ALK
AGA
BRAF
KRAS
MET
RET

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