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A multi-institutional study on the association between BRCA1/BRCA2 mutational status and triple-negative breast cancer in familial breast cancer patients.

Breast cancer research and treatment - 1 Jul 2014

Seong Moon-Woo, Kim Kyu Hyung, Chung Il Yong, Kang Eunyoung, Lee Jong Won, Park Sue K, Lee Min Hyuk, Lee Jeong Eon, Noh Dong-Young, Son Byung Ho, Park Hai-Lin, Cho Sung Im, Park Sung Sup, Kim Sung-Won

Abstract excerpt

Triple-negative breast cancer (TNBC) accounts for 12-24 % of all breast cancers. Here, we studied 221 familial breast and/or ovarian cancer patients from 37 hospitals using a comprehensive approach to identify large genomic rearrangements (LGRs) as well as sequence variants, and investigated the association between BRCA1/2 mutational status and TNBC. We performed direct sequencing or mutation scanning followed by...

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Source

Identifiers

PMID: 24894343
DOI: 10.1007/s10549-014-3006-7

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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