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Germline Mutations in Triple-Negative Breast Cancer

1 Jan 2017

Abstract excerpt

Triple-negative breast cancer (TNBC) is associated with a poor prognosis and defines a subgroup of patients who do not benefit from endocrine or anti-HER2 therapy. Rather than being a biological entity, TNBC represents a heterogeneous disease, and further subtyping is necessary to establish targeted therapies. Germline mutational status may serve as a robust biomarker predicting therapy response, especially with...

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PMID: 28611536
DOI: 10.1159/000455999

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