Article
A pharmacogenetic study of ABCB1 polymorphisms and cyclosporine treatment response in patients with psoriasis in the Greek population.
The pharmacogenomics journal - 1 Dec 2014
Vasilopoulos Y, Sarri C, Zafiriou E, Patsatsi A, Stamatis C, Ntoumou E, Fassos I, Tsalta A, Karra A, Roussaki-Schulze A, Sotiriadis D, Mamuris Z, Sarafidou T
Abstract excerpt
Psoriasis affects 2-3% of the population, causing significant morbidity and financial burden. Immunosuppressive drugs such as cyclosporine are first line systemic therapies for moderate-to-severe forms. However, patients exhibit heterogeneity in their response to therapy, possibly due to genetic factors. The aim of the present study was to assess the ABCB1 T-129C, G1199A, C1236T, G2677T and C3435T...
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