Article
Insights into psoriasis and other inflammatory diseases from large-scale gene expression studies.
Human molecular genetics - 15 Aug 2001
Bowcock A M, Shannon W, Du F, Duncan J, Cao K, Aftergut K, Catier J, Fernandez-Vina M A, Menter A
Abstract excerpt
Approximately 2% of the Caucasian population is affected by psoriasis (PS); a chronic inflammatory skin disease triggered by both genetic and environmental risk factors. In addition to a major contribution from the HLA class I region, PS susceptibility loci have been mapped to a number of regions including 1q21, 3q21, 4qter, 14q31-q32, 17q24-q25, 19p13.3 and 20p. Some of these overlap with loci implicated in...
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