Article
NAD(P)H:quinone oxidoreductase 1 Pro187Ser polymorphism and expression do not cosegregate with clinico-pathological characteristics of human mammary tumors.
Pharmacogenetics and genomics - 1 Jul 2009
Hubackova Miluse, Vaclavikova Radka, Mrhalova Marcela, Kubackova Katerina, Kodet Roman, Gut Ivan, Soucek Pavel
Abstract excerpt
OBJECTIVE: The aim of this study was to further clarify the recently reported role of NAD(P)H:quinone oxidoreductase 1 (NQO1) as a strong prognostic and predictive factor in breast cancer. METHODS: NQO1 transcript levels were monitored in mammary tumors by real-time polymerase chain reaction. NQO...
Topics
- Breast Neoplasms
- Gene Expression Regulation, Neoplastic
- Genetic Predisposition to Disease
- Humans
- Immunohistochemistry
- Middle Aged
- NAD(P)H Dehydrogenase (Quinone)
- Polymorphism, Single Nucleotide
- Proline
- RNA, Messenger