Article
BRCA1/2 germline mutations and their clinical importance in Turkish breast cancer patients.
Cancer investigation - 1 Oct 2014
Cecener Gulsah, Egeli Unal, Tunca Berrin, Erturk Elif, Ak Secil, Gokgoz Sehsuvar, Tasdelen Ismet, Tezcan Gulcin, Demirdogen Elif, Bayram Nuran, Avci Nilufer, Evrensel Turkkan
Abstract excerpt
BRCA1/BRCA2 genes were screened in 117 patients with breast cancer by sequencing. Fourteen percent of patients tested positive for BRCA1/BRCA2 mutations. Four frame shift mutations, four pathogenic missense mutations, and 25 different sequence variations were detected. BRCA mutation positivity was significantly associated with Ki67 (p = .001). BRCA protein expressions were decreased in the patients harboring...
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