Article
Clinicopathologic features and genetic characteristics of the BRCA1/2 mutation in Turkish breast cancer patients.
Cancer genetics - 1 Jan 2020
Cecener Gulsah, Sabour Takanlou Leila, Sabour Takanlou Maryam, Egeli Unal, Eskiler Gamze Guney, Aksoy Secil, Unal Ufuk, Tezcan Havva, Eryilmaz Isil Ezgi, Gokgoz Mustafa Sehsuvar, Tunca Berrin, Cubukcu Erdem, Evrensel Turkkan, Cetintas Sibel, Tasdelen Ismet
Abstract excerpt
The aim of this study was to identify the frequency and spectrum of germline BRCA1/2 pathogenic alterations in a cohort of patients with breast carcinoma. In this study, a total of 603 breast cancer subjects from Turkey were screened for BRCA1/BRCA2 mutations using HDA and Sanger sequencing. In the present study, 21 BRCA1 and BRCA2 pathogenic variants were detected in 30 patients and BRCA1/2 mutations were...
Topics
- Adult
- BRCA1 Protein
- BRCA2 Protein
- Breast
- Breast Neoplasms
- Breast Neoplasms, Male
- DNA Mutational Analysis
- Disease-Free Survival
- Female
- Follow-Up Studies