The relationship between mutation carriage of BRCA1/2 and clinicopathological characteristics in women with breast cancer - experience from a diagnostic centre in Turkey.

Abstract excerpt

The 5-10% of breast cancers (BC) are hereditary, and BRCA1/2 are causative in 25% of those inherited. It was aimed to examine the BRCA1/2 genotype-BC phenotype relationship. In 170 female patients with BC, BRCA1/2 genes were investigated using Next Generation Sequencing. Demographic and clinicopathological characteristics of the patients and correlations of pedigree analysis with BRCA1/2 mutation status were...

Topics

• Humans
• Female
• Adult
• Middle Aged
• Turkey
• Breast Neoplasms
• BRCA1 Protein
• BRCA2 Protein
• Mutation
• Genetic Predisposition to Disease