Article
Family-specific, novel, deleterious germline variants provide a rich resource to identify genetic predispositions for BRCAx familial breast cancer.
BMC cancer - 26 Jun 2014
Wen Hongxiu, Kim Yeong C, Snyder Carrie, Xiao Fengxia, Fleissner Elizabeth A, Becirovic Dina, Luo Jiangtao, Downs Bradley, Sherman Simon, Cowan Kenneth H, Lynch Henry T, Wang San Ming
Abstract excerpt
BACKGROUND: Genetic predisposition is the primary risk factor for familial breast cancer. For the majority of familial breast cancer, however, the genetic predispositions remain unknown. All newly identified predispositions occur rarely in disease population, and the unknown genetic predispositions are estimated to reach up to total thousands. Family unit is the basic structure of genetics. Because it is an...
Topics
- Breast Neoplasms
- Exome
- Female
- Genes, BRCA1
- Genes, BRCA2
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Humans
- Models, Biological
- Pedigree