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Article

A novel transgenic mouse model carrying human Tribbles related protein 3 (TRB3) gene and its site specific phenotype.

Biological & pharmaceutical bulletin - 1 Jan 2014

Sakai Yuto, Fukamachi Katsumi, Futakuchi Mitsuru, Miyoshi Ichiro, Tsuda Hiroyuki, Suzui Masumi, Hayashi Hidetoshi

Abstract excerpt

Tribbles related protein 3 (TRB3) pseudokinase plays a crucial role in cell proliferation, migration and morphogenesis during development. In our recent study, an introduction of human TRB3 gene into mouse mammary tumor cells caused an increase of proliferation of tumor cells and their nuclear size. In the current study, to examine whether this gene causes de novo morphological changes in a specific organ site we...

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Identifiers

PMID: 24882419
DOI: 10.1248/bpb.b14-00260

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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