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Analysis of TFEB function in Ksp-Cadherin16 CRE mouse lines to model a particular type of renal cell carcinoma

2016-01-01

Abstract excerpt

TFE-fusion renal cell carcinomas (TFE-fusion RCCs) are caused by chromosomal translocations that lead to the overexpression of the TFE3 and TFEB genes Kauffman et al, 2014). The mechanisms causing kidney tumour development starting from TFE3/TFEB gene overexpression, remain largely uncharacterized and effective targeted therapies are yet to be identified, hence the need to model these diseases in an experimental a...

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Literature Corpus work
01848c05-6e53-5a0e-94fa-2ac2847df387
DOI
10.21954/ou.ro.0000f6d7
Open publication

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Analysis of TFEB function in Ksp-Cadherin16 CRE mouse lines to model a particular type of renal cell carcinomaDOI 10.21954/ou.ro.0000f6d7
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