Article
FGFR3 mutations, but not FGFR3 expression and FGFR3 copy-number variations, are associated with favourable non-muscle invasive bladder cancer.
Virchows Archiv : an international journal of pathology - 1 Aug 2014
Neuzillet Yann, van Rhijn Bas W G, Prigoda Nadia L, Bapat Bharati, Liu Liyang, Bostrom Peter J, Fleshner Neil E, Gallie Brenda L, Zlotta Alexandre R, Jewett Michael A S, van der Kwast Theo H
Abstract excerpt
The fibroblast growth factor receptor 3 (FGFR3) is a tyrosine kinase receptor frequently activated by point mutations in bladder cancer (BC). These mutations are associated with genetically stable, Ta and low-grade BC, representing the favourable BC pathway. Conversely, FGFR3 over-expression was recently found in 40 % of muscle invasive BC. We examined FGFR3 mutation status and protein expression in patients...
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