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Article

Fibroblast growth factor receptor (FGFR) gene amplifications are rare events in bladder cancer.

Histopathology - 1 Apr 2015

Fischbach Anna, Rogler Anja, Erber Ramona, Stoehr Robert, Poulsom Richard, Heidenreich Axel, Schneevoigt Birte-Swantje, Hauke Sven, Hartmann Arndt, Knuechel Ruth, Veeck Jürgen, Gaisa Nadine T

Abstract excerpt

AIMS: Activating point mutations and protein overexpression of fibroblast growth factor receptors (FGFRs), especially FGFR3, are frequent events in bladder cancer. Little is known about gene amplifications, therefore we characterized amplification of FGFR1-3 by fluorescence in-situ hybridization (FISH). METHODS AND RESULTS: Tumours of 153 patients (n = 65 pTa low-grade, n = 15 pTa high-grade, n = 37 pT1, n = 20...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24898159
DOI: 10.1111/his.12473

Genes

FGFR3
FGFR1
FGFR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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