Article
CDKN2A homozygous deletion is associated with muscle invasion in FGFR3-mutated urothelial bladder carcinoma.
The Journal of pathology - 1 Jul 2012
Rebouissou Sandra, Hérault Aurélie, Letouzé Eric, Neuzillet Yann, Laplanche Agnès, Ofualuka Karina, Maillé Pascale, Leroy Karen, Riou Audrey, Lepage May-Linda, Vordos Dimitri, de la Taille Alexandre, Denoux Yves, Sibony Mathilde, Guyon Frédéric, Lebret Thierry, Benhamou Simone, Allory Yves, Radvanyi François
Abstract excerpt
The gene cyclin-dependent kinase inhibitor 2A (CDKN2A) is frequently inactivated by deletion in bladder carcinoma. However, its role in bladder tumourigenesis remains unclear. We investigated the role of CDKN2A deletion in urothelial carcinogenesis, as a function of FGFR3 mutation status, a marker for one of the two pathways of bladder tumour progression, the Ta pathway. We studied 288 bladder carcinomas: 177...
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