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Article

Is LRIG1 a Tumour Suppressor Gene at Chromosome 3p14.3?

1 Jan 2002

Abstract excerpt

The LRIG1 gene (formerly LIG-1), recently cloned by us, displays structural similarities to the Drosophila Kek I gene. Kek I encodes a cell surface protein, Kekkon-1, which inhibits epidermal growth factor receptor-mediated signalling. We localized the LRIG1 gene to chromosome band 3p14.3, a region known to be deleted in various human cancers. In the present study LRIG1 gene expression was examined in different...

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PMID: 12234026
DOI: 10.1080/028418602760169398

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