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Aberrant promoter methylation contributes to LRIG1 silencing in basal/triple-negative breast cancer

19 Apr 2022

Abstract excerpt

BACKGROUND: LRIG1, the founding member of the LRIG (leucine-rich repeat and immunoglobulin-like domain) family of transmembrane proteins, is a negative regulator of receptor tyrosine kinases and a tumour suppressor. Decreased LRIG1 expression is consistently observed in cancer, across diverse tumour types, and is linked to poor patient prognosis. However, mechanisms by which LRIG1 is repressed are not fully...

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PMID: 35440669
DOI: 10.1038/s41416-022-01812-8

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