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Article

DIRAS3 regulates the autophagosome initiation complex in dormant ovarian cancer cells

10 Apr 2014

Abstract excerpt

DIRAS3 is an imprinted tumor suppressor gene that is downregulated in 60% of human ovarian cancers. Re-expression of DIRAS3 at physiological levels inhibits proliferation, decreases motility, induces autophagy, and regulates tumor dormancy. Functional inhibition of autophagy with choroquine in dormant xenografts that express DIRAS3 significantly delays tumor regrowth after DIRAS3 levels are reduced, suggesting...

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Share to Autophagy in Disease and Therapy
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PMID: 24879154
DOI: 10.4161/auto.28577

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