Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of LncRNA THUMPD3-AS1 enhances olaparib-induced autophagy in BRCA mutant ovarian cancer cells via PI3K pathway.

Cellular signalling - 1 Oct 2026

Mu Qingling, Wang Xin, Guo Li, Liu Ying, Liu Dan, Xia Baoguo

Abstract excerpt

Ovarian carcinoma (OC) is a fatal malignant tumor that seriously threatens the health and survival of women. Olaparib is a highly promising drug for OC treatment of ovarian cancer. Long non-coding RNA (lncRNA) THUMPD3-AS1, which is related to autophagy, has been proven to be carcinogenic in OC. However, the effects and mechanisms of THUMPD3-AS1 combined with Olaparib on ovarian cancer remain unclear. Upregulation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy
Share to Mice, Nude
Share to Phthalazines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Piperazines

Share to Proto-Oncogene Proteins c-akt

Share to RNA, Long Noncoding

Share to TOR Serine-Threonine Kinases

Share to tRNA Methyltransferases

Source

Identifiers

PMID: 42259465
DOI: 10.1016/j.cellsig.2026.112662

Genes

THUMPD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of LncRNA THUMPD3-AS1 enhances olaparib-induced autophagy in BRCA mutant ovarian cancer cells via PI3K pathway.PMID 42259465Read ↗

THUMPD3-AS1 inhibits ovarian cancer cell apoptosis through the miR-320d/ARF1 axisSemantic proximity Read ↗

Autophagy-related long non-coding RNA signature for ovarian cancerSemantic proximity Read ↗

Danusertib Induces Apoptosis, Cell Cycle Arrest, and Autophagy but Inhibits Epithelial to Mesenchymal Transition Involving PI3K/Akt/mTOR Signaling Pathway in Human Ovarian Cancer Cells.Semantic proximity Read ↗

LncRNA GAS8-AS1 Inhibits Ovarian Cancer Progression Through Activating Beclin1-Mediated AutophagySemantic proximity Read ↗

UBE2T is upregulated, predicts poor prognosis, and promotes cell proliferation and invasion by promoting epithelial-mesenchymal transition via inhibiting autophagy in an AKT/mTOR dependent manner in ovarian cancerSemantic proximity Read ↗

LncRNA OTUD6B-AS1 promotes paclitaxel resistance in triple negative breast cancer by regulation of miR-26a-5p/MTDH pathway-mediated autophagy and genomic instabilitySemantic proximity Read ↗

ZFAS1 Orchestrates Stress-Induced Autophagy in Ovarian Cancer via miR302 Suppression and BNIP3L UpregulationSemantic proximity Read ↗

Melatonin increases Olaparib sensitivity and suppresses cancer-associated fibroblast infiltration via suppressing the LAMB3-CXCL2 axis in TNBCSemantic proximity Read ↗

A long noncoding RNA AB073614 promotes tumorigenesis and predicts poor prognosis in ovarian cancerSemantic proximity Read ↗

MicroRNA320e augments the synthetic lethality of olaparib by regulating homologous recombination repair via PI3K-AKT-mTOR pathwaySemantic proximity Read ↗

Regulation of ULK1 by WTAP/IGF2BP3 axis enhances mitophagy and progression in epithelial ovarian cancerSemantic proximity Read ↗

Cezanne promoted autophagy through PIK3C3 stabilization and PIK3C2A transcription in lung adenocarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.