Genome-wide analyses of ChIP-Seq derived FOXA2 DNA occupancy in liver points to genetic networks underpinning multiple complex traits.

doi:10.1210/jc.2013-4503

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Article

Genome-wide analyses of ChIP-Seq derived FOXA2 DNA occupancy in liver points to genetic networks underpinning multiple complex traits.

The Journal of clinical endocrinology and metabolism - 1 Aug 2014

Johnson Matthew E, Schug Jonathan, Wells Andrew D, Kaestner Klaus H, Grant Struan F A

Abstract excerpt

BACKGROUND: Forkhead Box A2 (FOXA2) exerts an influence on glucose homeostasis via activity in the liver. In addition, a key genome-wide association study (GWAS) recently demonstrated that genetic variation, namely rs6048205, at the FOXA2 locus is robustly associated with fasting glucose levels. Our hypothesis was that this DNA-binding protein regulates the expression of a set of molecular pathways critical to...

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PMID: 24878043
DOI: 10.1210/jc.2013-4503
PMCID: PMC4121035

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FOXA2

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