Evaluation of KDR rs34231037 as a predictor of sunitinib efficacy in patients with metastatic renal cell carcinoma.

doi:10.1097/FPC.0000000000000280

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Article

Evaluation of KDR rs34231037 as a predictor of sunitinib efficacy in patients with metastatic renal cell carcinoma.

Pharmacogenetics and genomics - 1 Jun 2017

Apellániz-Ruiz María, Diekstra Meta H, Roldán Juan M, Boven Epie, Castellano Daniel, Gelderblom Hans, Mathijssen Ron H J, Swen Jesse J, Böhringer Stefan, García-Donás Jesús, Rini Brian I, Guchelaar Henk-Jan, Rodríguez-Antona Cristina

Abstract excerpt

The identification of biomarkers able to predict clinical benefit from vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors is urgently needed. Recently, Maitland and colleagues described an association between KDR-rs34231037 and soluble VEGFR2 levels as well as pazopanib pharmacodynamics. We investigated in a well-characterized series of metastatic clear cell renal cell carcinoma...

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PMID: 28430711
DOI: 10.1097/FPC.0000000000000280

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