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Article

MMP-9 gene ablation mitigates hyperhomocystenemia-induced cognition and hearing dysfunction.

Molecular biology reports - 1 Aug 2014

Bhargava Seema, Pushpakumar Sathnur, Metreveli Naira, Givvimani Srikanth, Tyagi Suresh C

Abstract excerpt

Hyperhomocysteinemia (HHcy) is associated with cognitive decline and hearing loss due to vascular dysfunction. Although we have shown that HHcy-induced increased expression of matrix metalloproteinase-9 (MMP-9) is associated with cochlear pathology in cystathionine-β-synthase heterozygous (CBS(+/-)) mice, it is still unclear whether MMP-9 contributes to functional deficit in cognition and hearing. Therefore, we...

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Identifiers

PMID: 24874304
DOI: 10.1007/s11033-014-3425-x

Genes

CBS
ABR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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