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Article

Hyperhomocysteinemia-Induced Gene Expression Changes in the Cell Types of the Brain

1 Nov 2017

Abstract excerpt

High plasma levels of homocysteine, termed hyperhomocysteinemia, are a risk factor for vascular cognitive impairment and dementia, which is the second leading cause of dementia. While hyperhomocysteinemia induces microhemorrhages and cognitive decline in mice, the specific effect of hyperhomocysteinemia on each cell type remains unknown. We took separate cultures of astrocytes, microglia, endothelial cells, and...

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PMID: 29198136
DOI: 10.1177/1759091417742296

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