Article
Stroke in young patients with hyperhomocysteinemia due to cystathionine beta-synthase deficiency.
Neurology - 28 Jan 2003
Kelly P J, Furie K L, Kistler J P, Barron M, Picard E H, Mandell R, Shih V E
Abstract excerpt
BACKGROUND: Although hyperhomocyst(e)inemia (Hyper-Hcy) may predispose to atherosclerosis and venous thrombosis, the mechanisms of stroke associated with Hyper-Hcy are not defined. METHODS: Clinical and biochemical phenotypes and genetic features of three unrelated patients with premature stroke and severe Hyper-Hcy due to cystathionine beta-synthase (CBS) deficiency are described. Plasma Hcy and amino acids were...
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