Article
BRAF(V600E) mutation together with loss of Trp53 or pTEN drives the origination of hairy cell leukemia from B-lymphocytes.
Molecular cancer - 5 Aug 2023
Yap Jiajun, Yuan Jimin, Ng Wan Hwa, Chen Gao Bin, Sim Yuen Rong M, Goh Kah Chun, Teo Joey, Lim Trixie Y H, Goay Shee Min, Teo Jia Hao Jackie, Lao Zhentang, Lam Paula, Sabapathy Kanaga, Hu Jiancheng
Abstract excerpt
Hairy cell leukemia (HCL) is a B-lymphoma induced by BRAF(V600E) mutation. However, introducing BRAF(V600E) in B-lymphocytes fails to induce hematological malignancy, suggesting that BRAF(V600E) needs concurrent mutations to drive HCL ontogeny. To resolve this issue, here we surveyed human HCL genomic sequencing data. Together with previous reports, we speculated that the tumor suppressor TP53, P27, or PTEN...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.