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Article

Validation of ZAP-70 methylation and its relative significance in predicting outcome in chronic lymphocytic leukemia

28 May 2014

Abstract excerpt

ZAP-70 methylation 223 nucleotides downstream of transcription start (CpG+223) predicts outcome in chronic lymphocytic leukemia (CLL), but its impact relative to CD38 and ZAP-70 expression or immunoglobulin heavy chain variable region (IGHV) status is uncertain. Additionally, standardizing ZAP-70 expression analysis has been unsuccessful. CpG+223 methylation was quantitatively determined in 295 untreated CLL...

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PMID: 24868078
DOI: 10.1182/blood-2014-02-555722

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