Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel molecular diagnostic marker for familial and early-onset coronary artery disease and myocardial infarction in the LRP8 gene.

Circulation. Cardiovascular genetics - 1 Aug 2014

Shen Gong-Qing, Girelli Domenico, Li Lin, Rao Shaoqi, Archacki Stephen, Olivieri Oliviero, Martinelli Nicola, Park Jeong Euy, Chen Qiuyun, Topol Eric J, Wang Qing K

Abstract excerpt

BACKGROUND: Many single-nucleotide polymorphisms have been associated with coronary artery disease (CAD)/myocardial infarction (MI) by genome-wide association studies, but the diagnostic value of these variants is limited. Functional single-nucleotide polymorphism R952Q in LRP8 is associated with familial and early-onset CAD/MI. The objective of this study is to test whether fine mapping and haplotype analysis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Cholesterol, LDL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Coronary Artery Disease

Share to LDL-Receptor Related Proteins

Share to Myocardial Infarction

Share to Republic of Korea

Source

Open in PubMed Open full text

Identifiers

PMID: 24867879
DOI: 10.1161/CIRCGENETICS.113.000321
PMCID: PMC4140990

Genes

CAD
LRP8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel molecular diagnostic marker for familial and early-onset coronary artery disease and myocardial infarction in the LRP8 gene.PMID 24867879Read ↗

Multi-allelic haplotype association identifies novel information different from single-SNP analysis: a new protective haplotype in the LRP8 gene is against familial and early-onset CAD and MI.Semantic proximity Read ↗

An LRP8 variant is associated with familial and premature coronary artery disease and myocardial infarction.Semantic proximity Read ↗

Genetic variant R952Q in LRP8 is associated with increased plasma triglyceride levels in patients with early-onset CAD and MI.Semantic proximity Read ↗

Molecular genetics of coronary artery disease.Semantic proximity Read ↗

TG haplotype in the LRP8 is associated with myocardial infarction in south Indian population.Semantic proximity Read ↗

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction.Semantic proximity Read ↗

Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.Semantic proximity Read ↗

Large scale association analysis identifies three susceptibility loci for coronary artery disease.Semantic proximity Read ↗

Blood lipid-related low-frequency variants in LDLR and PCSK9 are associated with onset age and risk of myocardial infarction in Japanese.Semantic proximity Read ↗

Genome-wide linkage scan identifies two novel genetic loci for coronary artery disease: in GeneQuest families.Semantic proximity Read ↗

Genetic loci associated with prevalent and incident myocardial infarction and coronary heart disease in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium.Semantic proximity Read ↗

The discovery of genes implicated in myocardial infarction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.