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Article

Genetic variant R952Q in LRP8 is associated with increased plasma triglyceride levels in patients with early-onset CAD and MI.

Annals of human genetics - 1 May 2012

Shen Gong-Qing, Li Lin, Wang Qing K

Abstract excerpt

We previously identified a novel locus for plasma triglyceride (TG) levels on chromosome 1p31-32 by genome-wide linkage analysis in the GeneQuest population with familial and premature coronary artery disease (CAD). Here we tested a hypothesis that variants in LRP8, a gene that is under the 1p31-32 linkage peak and associated with risk of familial and premature CAD and increased platelet activation, are...

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Source

Identifiers

PMID: 22404453
DOI: 10.1111/j.1469-1809.2012.00705.x

Genes

CAD
LRP8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic variant R952Q in LRP8 is associated with increased plasma triglyceride levels in patients with early-onset CAD and MI.PMID 22404453Read ↗

Identification of a novel locus for triglyceride on chromosome 1p31-32 in families with premature CAD and MI.Semantic proximity Read ↗

Multi-allelic haplotype association identifies novel information different from single-SNP analysis: a new protective haplotype in the LRP8 gene is against familial and early-onset CAD and MI.Semantic proximity Read ↗

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