Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Blood lipid-related low-frequency variants in LDLR and PCSK9 are associated with onset age and risk of myocardial infarction in Japanese.

Scientific reports - 25 May 2018

Tajima Tomoyuki, Morita Hiroyuki, Ito Kaoru, Yamazaki Tsutomu, Kubo Michiaki, Komuro Issei, Momozawa Yukihide

Abstract excerpt

Recent studies have revealed the importance of rare variants in myocardial infarction (MI) susceptibility in European populations. Because genetic architectures vary in different populations, we investigated how they contribute to MI susceptibility in Japanese subjects. We performed targeted sequencing of 36 coronary artery disease risk genes, identified by genome-wide association studies, in 9,956 cases and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholesterol, LDL

Share to Genetic Variation

Share to Myocardial Infarction

Share to Proprotein Convertase 9

Share to Receptors, LDL

Source

Open in PubMed Open full text

Identifiers

PMID: 29802317
DOI: 10.1038/s41598-018-26453-x
PMCID: PMC5970143

Genes

LDLR
PCSK9

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Blood lipid-related low-frequency variants in LDLR and PCSK9 are associated with onset age and risk of myocardial infarction in Japanese.PMID 29802317Read ↗

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction.Semantic proximity Read ↗

A genome-wide association study identifies PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for myocardial infarction in Japanese.Semantic proximity Read ↗

Impact of genetic markers related to hyper-HDL cholesterol on the prevalence of myocardial infarction: a KoGES study.Semantic proximity Read ↗

Association of genetic variants with myocardial infarction in Japanese individuals with different lipid profiles.Semantic proximity Read ↗

Genome-wide analyses of early-onset acute myocardial infarction identify 29 novel loci by whole genome sequencingSemantic proximity Read ↗

Pooled DNA resequencing of 68 myocardial infarction candidate genes in French canadians.Semantic proximity Read ↗

TG haplotype in the LRP8 is associated with myocardial infarction in south Indian population.Semantic proximity Read ↗

Association of six genetic variants with myocardial infarction.Semantic proximity Read ↗

Identification of 187 single nucleotide polymorphisms (SNPs) among 41 candidate genes for ischemic heart disease in the Japanese population.Semantic proximity Read ↗

A novel molecular diagnostic marker for familial and early-onset coronary artery disease and myocardial infarction in the LRP8 gene.Semantic proximity Read ↗

Lipid-associated genetic polymorphisms are associated with FBP and LDL-c levels among myocardial infarction patients in Chinese population.Semantic proximity Read ↗

Genetic loci associated with prevalent and incident myocardial infarction and coronary heart disease in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) ConsortiumSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.