Article
Genetic loci associated with prevalent and incident myocardial infarction and coronary heart disease in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium.
PloS one - 1 Jan 2020
Hahn Julie, Fu Yi-Ping, Brown Michael R, Bis Joshua C, de Vries Paul S, Feitosa Mary F, Yanek Lisa R, Weiss Stefan, Giulianini Franco, Smith Albert Vernon, Guo Xiuqing, Bartz Traci M, Becker Diane M, Becker Lewis C, Boerwinkle Eric, Brody Jennifer A, Chen Yii-Der Ida, Franco Oscar H, Grove Megan, Harris Tamara B, Hofman Albert, Hwang Shih-Jen, Kral Brian G, Launer Lenore J, Markus Marcello R P, Rice Kenneth M, Rich Stephen S, Ridker Paul M, Rivadeneira Fernando, Rotter Jerome I, Sotoodehnia Nona, Taylor Kent D, Uitterlinden André G, Völker Uwe, Völzke Henry, Yao Jie, Chasman Daniel I, Dörr Marcus, Gudnason Vilmundur, Mathias Rasika A, Post Wendy, Psaty Bruce M, Dehghan Abbas, O'Donnell Christopher J, Morrison Alanna C
Abstract excerpt
BACKGROUND: Genome-wide association studies have identified multiple genomic loci associated with coronary artery disease, but most are common variants in non-coding regions that provide limited information on causal genes and etiology of the disease. To overcome the limited scope that common variants provide, we focused our investigation on low-frequency and rare sequence variations primarily residing in coding...
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