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Article

SPARC regulates microgliosis and functional recovery following cortical ischemia.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 6 Mar 2013

Lloyd-Burton Samantha M, York Elisa M, Anwar Mohammad A, Vincent Adele J, Roskams A Jane

Abstract excerpt

Secreted protein acidic rich in cysteine (SPARC) is a matricellular protein that modulates the activity of growth factors, cytokines, and extracellular matrix to play multiple roles in tissue development and repair, such as cellular adhesion, migration, and proliferation. Throughout the CNS, SPARC is highly localized in mature ramified microglia, but its role in microglia--in development or during response to...

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Source

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Identifiers

PMID: 23467362
DOI: 10.1523/JNEUROSCI.3585-12.2013
PMCID: PMC6704956

Genes

SPARC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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