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Article

HSP27 mediates SPARC‐induced changes in glioma morphology, migration, and invasion

28 Apr 2008

Abstract excerpt

Secreted protein acidic and rich in cysteine (SPARC) regulates cell-extracellular matrix interactions that influence cell adhesion and migration. We have demonstrated that SPARC is highly expressed in human gliomas, and it promotes brain tumor invasion in vitro and in vivo. To further our understanding regarding SPARC function in glioma migration, we transfected SPARC-green fluorescent protein (GFP) and control...

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PMID: 18442089
DOI: 10.1002/glia.20679

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