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Article

Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia.

Proceedings of the National Academy of Sciences of the United States of America - 2 Mar 2004

Chubanov Vladimir, Waldegger Siegfried, Mederos y Schnitzler Michael, Vitzthum Helga, Sassen Martin C, Seyberth Hannsjörg W, Konrad Martin, Gudermann Thomas

Abstract excerpt

Impaired magnesium reabsorption in patients with TRPM6 gene mutations stresses an important role of TRPM6 (melastatin-related TRP cation channel) in epithelial magnesium transport. While attempting to isolate full-length TRPM6, we found that the human TRPM6 gene encodes multiple mRNA isoforms. Fu...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 14976260
DOI: 10.1073/pnas.0305252101
PMCID: PMC365716

Genes

TRPM6
TRPM7

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14976260-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

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Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia.PMID 14976260Read ↗

Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family.Semantic proximity Read ↗

TRPM6 kinase activity regulates TRPM7 trafficking and inhibits cellular growth under hypomagnesic conditions.Semantic proximity Read ↗

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Novel TRPM6 mutations in 21 families with primary hypomagnesemia and secondary hypocalcemia.Semantic proximity Read ↗

TRPM7: a unique channel involved in magnesium homeostasis.Semantic proximity Read ↗

Transient receptor potential melastatin 6 knockout mice are lethal whereas heterozygous deletion results in mild hypomagnesemia.Semantic proximity Read ↗

New molecular players facilitating Mg(2+) reabsorption in the distal convoluted tubule.Semantic proximity Read ↗

The rise and fall of novel renal magnesium transportersSemantic proximity Read ↗

A Novel Homozygous Mutation in the Transient Receptor Potential Melastatin 6 Gene: A Case Report.Semantic proximity Read ↗

Adult-Onset Hypomagnesemia With Secondary Hypocalcemia Caused by a Novel Variant in TRPM6 Gene: A Case Report.Semantic proximity Read ↗

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