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Article

Kinetic investigation of the rate-limiting step of manganese- and iron-lipoxygenases.

Archives of biochemistry and biophysics - 1 Aug 2014

Wennman Anneli, Karkehabadi Saeid, Oliw Ernst H

Abstract excerpt

Lipoxygenases (LOX) oxidize polyunsaturated fatty acids to hydroperoxides, which are generated by proton coupled electron transfer to the metal center with FeIIIOH- or MnIIIOH-. Hydrogen abstraction by FeIIIOH- of soybean LOX-1 (sLOX-1) is associated with a large deuterium kinetic isotope effect (D-KIE). Our goal was to compare the D-KIE and other kinetic parameters at different temperatures of sLOX-1 with...

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Source

Identifiers

PMID: 24857825
DOI: 10.1016/j.abb.2014.05.014

Genes

LOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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