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The Soybean Lipoxygenase-Substrate Complex: Correlation between the Properties of Tunneling-Ready States and ENDOR-Detected Structures of Ground States.

Biochemistry - 25 Feb 2020

Offenbacher Adam R, Sharma Ajay, Doan Peter E, Klinman Judith P, Hoffman Brian M

Abstract excerpt

Hydrogen tunneling in enzymatic C-H activation requires a dynamical sampling among ground-state enzyme-substrate (E-S) conformations, which transiently generates a tunneling-ready state (TRS). The TRS is characterized by a hydrogen donor-acceptor distance (DAD) of 2.7 Å, ∼0.5 Å shorter than the dominant DAD of optimized ground states. Recently, a high-resolution, 13C electron-nuclear double-resonance (ENDOR)...

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Identifiers

PMID: 32022556
DOI: 10.1021/acs.biochem.9b00861
PMCID: PMC7188194

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