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Article

Extremely elevated room-temperature kinetic isotope effects quantify the critical role of barrier width in enzymatic C-H activation.

Journal of the American Chemical Society - 11 Jun 2014

Hu Shenshen, Sharma Sudhir C, Scouras Alexander D, Soudackov Alexander V, Carr Cody A Marcus, Hammes-Schiffer Sharon, Alber Tom, Klinman Judith P

Abstract excerpt

The enzyme soybean lipoxygenase (SLO) has served as a prototype for hydrogen-tunneling reactions, as a result of its unusual kinetic isotope effects (KIEs) and their temperature dependencies. Using a synergy of kinetic, structural, and theoretical studies, we show how the interplay between donor-acceptor distance and active-site flexibility leads to catalytic behavior previously predicted by quantum tunneling...

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Identifiers

PMID: 24884374
DOI: 10.1021/ja502726s
PMCID: PMC4188422

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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