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Article

Catalytic convergence of manganese and iron lipoxygenases by replacement of a single amino acid.

The Journal of biological chemistry - 14 Sept 2012

Wennman Anneli, Jernerén Fredrik, Hamberg Mats, Oliw Ernst H

Abstract excerpt

Lipoxygenases (LOXs) contain a hydrophobic substrate channel with the conserved Gly/Ala determinant of regio- and stereospecificity and a conserved Leu residue near the catalytic non-heme iron. Our goal was to study the importance of this region (Gly(332), Leu(336), and Phe(337)) of a lipoxygenase with catalytic manganese (13R-MnLOX). Recombinant 13R-MnLOX oxidizes 18:2n-6 and 18:3n-3 to 13R-, 11(S or R)-, and...

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Identifiers

PMID: 22822060
DOI: 10.1074/jbc.M112.364331
PMCID: PMC3442510

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LOX

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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