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Article

Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects.

Cell reports - 12 Jun 2014

Mullen Andrew R, Hu Zeping, Shi Xiaolei, Jiang Lei, Boroughs Lindsey K, Kovacs Zoltan, Boriack Richard, Rakheja Dinesh, Sullivan Lucas B, Linehan W Marston, Chandel Navdeep S, DeBerardinis Ralph J

Abstract excerpt

Mammalian cells generate citrate by decarboxylating pyruvate in the mitochondria to supply the tricarboxylic acid (TCA) cycle. In contrast, hypoxia and other impairments of mitochondrial function induce an alternative pathway that produces citrate by reductively carboxylating α-ketoglutarate (AKG) via NADPH-dependent isocitrate dehydrogenase (IDH). It is unknown how cells generate reducing equivalents necessary...

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Identifiers

PMID: 24857658
DOI: 10.1016/j.celrep.2014.04.037
PMCID: PMC4057960

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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