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Article

Wnt/β-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours.

The EMBO journal - 17 Jul 2013

Wend Peter, Fang Liang, Zhu Qionghua, Schipper Jörg H, Loddenkemper Christoph, Kosel Frauke, Brinkmann Volker, Eckert Klaus, Hindersin Simone, Holland Jane D, Lehr Stephan, Kahn Michael, Ziebold Ulrike, Birchmeier Walter

Abstract excerpt

We show that activation of Wnt/β-catenin and attenuation of Bmp signals, by combined gain- and loss-of-function mutations of β-catenin and Bmpr1a, respectively, results in rapidly growing, aggressive squamous cell carcinomas (SCC) in the salivary glands of mice. Tumours contain transplantable and hyperproliferative tumour propagating cells, which can be enriched by fluorescence activated cell sorting (FACS)....

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Identifiers

PMID: 23736260
DOI: 10.1038/emboj.2013.127
PMCID: PMC3715856

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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