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Article

Programmed death 1 deficiency induces the polarization of macrophages/microglia to the M1 phenotype after spinal cord injury in mice.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics - 1 Jul 2014

Yao Anhui, Liu Fangfang, Chen Kun, Tang Liang, Liu Ling, Zhang Kun, Yu Caiyong, Bian Ganlan, Guo Hongmin, Zheng Jingjing, Cheng Peng, Ju Gong, Wang Jian

Abstract excerpt

The inflammatory response following spinal cord injury (SCI) involves the activation of resident microglia and the infiltration of macrophages. Macrophages and microglia can be polarized into the classically activated proinflammatory M1 phenotype or the alternatively activated anti-inflammatory M2 phenotype. Programmed cell death 1 (PD-1) is a critical immune inhibitory receptor involved in innate and adaptive...

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Identifiers

PMID: 24853068
DOI: 10.1007/s13311-013-0254-x
PMCID: PMC4121443

Genes

STAT1
STAT6

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