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Article

S100-β aggravates spinal cord injury via activation of M1 macrophage phenotype.

Journal of musculoskeletal & neuronal interactions - 1 Sept 2021

Duan Keke, Liu Shizhang, Yi Zhi, Liu Huitong, Li Jingyuan, Shi Jiyuan, Ji Le, Xu Bingqiang, Zhang Xiaoxia, Zhang Wei

Abstract excerpt

OBJECTIVES: S100-β has been identified as a sensitive biomarker in central nervous system injuries. However, the functions and mechanisms of S100-β are unknown in spinal cord injury. METHODS: Spinal cord injury (SCI) mouse model was generated by surgical operation, microglia activation model was established by inducing BV-2 cells with LPS. The SCI model was evaluated by Basso-Beattie-Bresnahan (BBB) behavioral...

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PMID: 34465680
PMCID: PMC8426655

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